PRP Vs PRF: What’s the Difference?

Sign Up

Sign up to stay connected to Enriched exciting new specials, services, and news.

Platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) are two different treatment types gaining popularity in the medical field over time. Both methods involve taking the patient’s blood sample and processing it to concentrate platelets and growth factors. The process ends with injecting the platelets into the affected patient’s area to promote healing. There is no denying that PRP and PRF have some similarities. However, they also have significant differences that everyone must know. 

Overall, while both PRP and PRF have shown promising results in promoting tissue healing and regeneration, newer research suggests that PRF may be the superior treatment option due to its higher concentration of platelets and healing factors, as well as its ability to promote the slower, more sustained release of growth factors. However, it is important to note that more research is needed to understand PRP and PRF’s potential benefits and limitations fully.

So, let’s discuss the differences between PRP vs PRF in this blog and why either is considered a superior treatment option for patients.

Blood Collection and Processing

Both PRP and PRF methods require a blood sample to be taken from the patient. However, the former requires more efficient blood collection than PRF. In both cases, the complete blood sample is placed into a centrifuge, where it is processed to help separate the blood into distinct layers for further inspection and analysis. 

PRP methods involve spinning at a higher speed, leading to all the heavier blood cells, such as the stem cells and white blood cells, to get to the bottom of the test tube effectively. It also enables the lighter platelets and plasma to collect in the topmost part of the test tube. The plasma and platelets are then concentrated from the upper portion of the same test tube where they get collected and injected into the particular region with specific tissue damage. 

Now, if we look at the PRF method, it involves spinning the platelets at a lower speed so that the blood layers do not separate out as distinctly. The process allows some of the stem cells and white blood cells to remain within the platelet layer collected for the specific treatment. So, there are more healing factors within PRF methods than in PRP methods of treatment. Moreover, the lower spin speed is known to cause little or no trauma to the individual cells of the blood. It allows more stem cells to remain in one of the finalized PRF products.

Platelet Concentration

One of the primary differences between PRP and PRF methods is regarding the specific concentration of different platelets. PRP contains 2-5 times the level of platelets found within the human body. However, newer literature and research state that an even higher platelet concentration within the human body may be more effective in treating tissue damage. PRF products contain approximately 10 times the platelet concentration, so they make for an effective method.

Higher platelet concentration can be beneficial to promote tissue regeneration and healing processes. It is because platelets contain growth factors that help stimulate tissue repair within a short period. So, more growth factors are introduced into the affected area by using a product with a higher concentration of platelets, which can lead to a more robust healing response. 


Another major difference between PRP and PRF is the use of anticoagulants during the blood processing phase. Then PRP continues with the collected blood getting placed in different test tubes through an anticoagulant called acid citrate dextrose (ACD). It keeps the specific blood product from clotting instantly. On the other hand, the PRF test tubes do not have any anticoagulant within them which is an effort to keep the platelet product as natural as possible.

If there are no anticoagulants, the human body will face various negative consequences. For instance, their absence may cause the natural fibrinogen within our blood to be converted to fibrin by thrombin in the early clot formation stages. The process creates a spongy fibrin matrix that helps activate the required platelets. It also allows a slow release of growth factors, which ultimately start the tissue healing process. The use of such anticoagulants in PRP can help dilute the platelet concentration and may reduce the effectiveness of the specific treatment.


Both PRP and PRF are known to be effective in promoting tissue healing and regeneration. However, the latest research studies suggest that PRF may be a superior treatment option. It has also been found by many research analysts that PRF produces better results in bone regeneration than PRP. Another study shows that PRF results in better bone density and higher implant stability than PRP. Moreover, researchers have further found that PRF is more effective than PRP in promoting damaged nerve tissue regeneration processes.

If that is not enough, PRF has also been shown to be effective in promoting wound healing. A study published in the Journal of Wound Care found that PRF was more effective than traditional wound dressings in treating chronic wounds, such as diabetic foot ulcers. Another study published in the Journal of Clinical and Diagnostic Research showed that PRF was effective in promoting the healing of postoperative wounds in patients undergoing orthopedic surgery.

Leukocyte Content

Another difference between PRP and PRF is the leukocyte content. Leukocytes refer to the white blood cells that play a significant role in the human body’s immune system. PRP contains a higher concentration of leukocytes. On the other hand, PRF contains a lower concentration or no leukocytes.

While some studies have suggested that the presence of leukocytes in PRP may enhance the healing process, other studies have shown that leukocytes can cause inflammation and inhibit tissue regeneration. In contrast, PRF’s lower leukocyte concentration can minimize inflammation. That makes it a better option for individuals with chronic or inflammatory conditions.

Preparation Time

Preparation time accounts for one of the most notable differences between PRP and PRF. For the unversed, PRP takes a shorter time to prepare, while PRF takes longer. On the other hand, PRP can be prepared in about 30 minutes, while PRF can take up to an hour to prepare.

PRP’s shorter preparation time makes it a more convenient option for some patients, but it may have a lower concentration of platelets and growth factors. In contrast, the longer preparation time required for PRF may result in a more concentrated and potent product that can promote more significant healing and regeneration.

The Bottom Line

Hence, PRPS and PRFs are two regenerative medicine treatments that have gained popularity in recent years because of their potential to promote tissue regeneration processes through healing and repair. While both methods have some similarities in terms of their use and perspectives, there are also some significant differences between the two methods. 

Did you know that PRF has a higher concentration of platelets and healing factors than PRP? It accounts for the specific method’s ability to promote a more sustained and slower release of significant growth factors. It is also shown to be effective in promoting nerve and bone tissue regeneration in human beings. The method further accounts for faster wound healing processes. However, scientists and medical researchers need to do more research to understand the potential benefits and limitations of PRP vs PRF completely. 

So, if you are considering regenerative medicine treatments, it is important to consult with a ENRICHED Med Spa to determine the best treatment option for your individual needs and circumstances.

There is no denying that both methods are significant in the medical field. However, it depends on the healthcare professionals, patients, and their respective requirements when it comes to choosing either method for further inspection or treatment analysis.


Preferred Day(s):

Select your service and preferred day below. Our team will confirm your time slot shortly.

Enriched Med Spa
19-3981 Major Mackenzie Dr. W
Woodbridge, ON L4H 4G1